Evaluation of Pharmacogenetic Algorithm for Warfarin Dose Requirements in Japanese Patients
نویسندگان
چکیده
منابع مشابه
Evaluation of pharmacogenetic algorithm for warfarin dose requirements in Japanese patients.
BACKGROUND Warfarin dosing is difficult to establish because of considerable interindividual variation. Thus, warfarin pharmacogenetics have attracted particular interest in relation to appropriate control of anticoagulation. METHODS AND RESULTS The 200 eligible subjects were chosen from participants in a hospital cohort. Performance of a pharmacogenetic algorithm recently developed by the In...
متن کاملEvaluation of CYP2C9- and VKORC1-based pharmacogenetic algorithm for warfarin dose in Gaza-Palestine
Aim To evaluate applicability of CYP2C9*2, *3 and VKORC1-1639G > A based algorithm to predict warfarin stable dose (WSD) in a group of Palestinian patients. Patients & methods Warfarin doses were retrospectively calculated for 101 Palestinian patients under warfarin therapy using three models. Performance of the three models was assessed in 47 patients found to take WSD. Results Frequency o...
متن کاملEstimation of the Warfarin Dose with Clinical and Pharmacogenetic Data
Copyright © 2009 Massachusetts Medical Society. Background Genetic variability among patients plays an important role in determining the dose of warfarin that should be used when oral anticoagulation is initiated, but practical methods of using genetic information have not been evaluated in a diverse and large population. We developed and used an algorithm for estimating the appropriate warfari...
متن کاملEstimation of the Warfarin Dose with Clinical and Pharmacogenetic Data
Copyright © 2009 Massachusetts Medical Society. Background Genetic variability among patients plays an important role in determining the dose of warfarin that should be used when oral anticoagulation is initiated, but practical methods of using genetic information have not been evaluated in a diverse and large population. We developed and used an algorithm for estimating the appropriate warfari...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Circulation Journal
سال: 2010
ISSN: 1346-9843,1347-4820
DOI: 10.1253/circj.cj-09-0876